347 research outputs found
Connections of the Mesencephalic Locomotor Region (MLR) in the Cat
The cat entopeduncular nucleus (EN), which is the main output of the basal ganglia, is known to project to the mesencephalic tegmentum. We have been able to elicit antidromic responses in single EN neurons from the region of the mesencephalic locomotor region (MLR), then transect (precollicular-postmamillary) the brainstem and elicit rhythmic movements of the limbs by stimulation of the same site in the same animal. Injections of the fluorescent dye 2,4 diamidino phenylindole 2 HCL (DAPI) into this area induces retrograde labeling of cell bodies in EN and motor cortex. Injections of a tritiated amino acid (leucine) into the motor cortex induce terminal labeling in the area of the MLR. These studies describe convergent projections from EN and motor cortex to the MLR. These connections may be involved in the sequencing and ordering of voluntary movements in which locomotion is necessary
Aplikasi Klinik Renograf Ir-03 Untuk Rumahsakit: Teknologi Dan Analisis Biaya
APLIKASI KLINIK RENOGRAF IR-03 UNTUK RUMAHSAKIT: TEKNOLOGI DAN ANALISIS BIAYA. TeknikRenografi menggunakan Alat Renograf adalah salah satu modalitas pemeriksaan fungsi ginjal selain denganpemeriksaan laboratorium dan teknik Sinar-X. Renograf IR-03 untuk pemeriksaan fungsi ginjal hasil rancangbangunBATAN telah dikonstruksi dan menjalani uji laboratorium di PRPN-BATAN Serpong dan uji klinis di RSUPDR.Sardjito Jogyakarta. Biaya yang berkaitan dengan pemakaian klinik Alat Renograf di rumahsakit telah dianalisisyang terdiri dari komponen nilai radiofarmaka dan nilai investasi alat Renograf. Perhitungan biaya radiofarmakahippuran 131Iodine per tahun dengan estimasi jumlah pasien 2000 orang sebesar Rp. 30 juta, Total Direct Costadalah Rp. 212,5 juta dan biaya modal satu Alat Renograf sebesar Rp. 250 juta. Nilai Titik Impas (Break EventPoint) Investasi satu Alat Renograf adalah 1194 (0,597%) atau setara Rp. 209,475 juta, dengan biaya per proseduradalah Rp. 85.000,-. Harga ini tergantung pada beberapa variable terutama volume (kapasitas pelayanan pasien).Perhitungan analisis Cash-Flow untuk melihat seberapa jauh investasi tersebut menarik dan memberi prospek kemasa depan menunjukkan nilai Rate of Return yang diperoleh yaitu ROR ( i*) adalah 22,6%, jauh diatas suku bungasimpanan Bank saat ini yaitu <10%. Perhitungan analisa Payback Period menunjukkan nilai 1,818 tahun, sangatprospektif secara ekonomi
Negative-index bi-anisotropic photonic metamaterial fabricated by direct laser writing and silver shadow evaporation
We present the blueprint for a novel negative-index metamaterial. This
structure is fabricated via three-dimensional two-photon direct laser writing
and silver shadow evaporation. The comparison of measured linear optical
spectra with theory shows good agreement and reveals a negative real part of
the refractive index at around 3.85 micrometer wavelength - despite the fact
that the metamaterial structure is bi-anisotropic due to the lack of inversion
symmetry along its surface normal.Comment: 8 pages, 3 figure
Basic tasks of sentiment analysis
Subjectivity detection is the task of identifying objective and subjective
sentences. Objective sentences are those which do not exhibit any sentiment.
So, it is desired for a sentiment analysis engine to find and separate the
objective sentences for further analysis, e.g., polarity detection. In
subjective sentences, opinions can often be expressed on one or multiple
topics. Aspect extraction is a subtask of sentiment analysis that consists in
identifying opinion targets in opinionated text, i.e., in detecting the
specific aspects of a product or service the opinion holder is either praising
or complaining about
Surface Scaling Analysis of a Frustrated Spring-network Model for Surfactant-templated Hydrogels
We propose and study a simplified model for the surface and bulk structures
of crosslinked polymer gels, into which voids are introduced through templating
by surfactant micelles. Such systems were recently studied by Atomic Force
Microscopy [M. Chakrapani et al., e-print cond-mat/0112255]. The gel is
represented by a frustrated, triangular network of nodes connected by springs
of random equilibrium lengths. The nodes represent crosslinkers, and the
springs correspond to polymer chains. The boundaries are fixed at the bottom,
free at the top, and periodic in the lateral direction. Voids are introduced by
deleting a proportion of the nodes and their associated springs. The model is
numerically relaxed to a representative local energy minimum, resulting in an
inhomogeneous, ``clumpy'' bulk structure. The free top surface is defined at
evenly spaced points in the lateral (x) direction by the height of the topmost
spring, measured from the bottom layer, h(x). Its scaling properties are
studied by calculating the root-mean-square surface width and the generalized
increment correlation functions C_q(x)= . The surface is
found to have a nontrivial scaling behavior on small length scales, with a
crossover to scale-independent behavior on large scales. As the vacancy
concentration approaches the site-percolation limit, both the crossover length
and the saturation value of the surface width diverge in a manner that appears
to be proportional to the bulk connectivity length. This suggests that a
percolation transition in the bulk also drives a similar divergence observed in
surfactant templated polyacrylamide gels at high surfactant concentrations.Comment: 17 pages RevTex4, 10 imbedded eps figures. Expanded discussion of
multi-affinit
Symmetries of Electrostatic Interaction between DNA Molecules
We study a model for pair interaction of DNA molecules generated by the
discrete dipole moments of base-pairs and the charges of phosphate groups, and
find noncommutative group of eighth order of symmetries that leave
invariant. We classify the minima using group and employ
numerical methods for finding them. The minima may correspond to several
cholesteric phases, as well as phases formed by cross-like conformations of
molecules at an angle close to , "snowflake phase". The results
depend on the effective charge of the phosphate group which can be modified
by the polycations or the ions of metals. The snowflake phase could exist for
above the threshold . Below there could be several cholesteric
phases. Close to the snowflake phase could change into the cholesteric
one at constant distance between adjacent molecules.Comment: 13 pages, 4 figure
Restoration of Frequency-Dependent Depression of the H-Reflex by Passive Exercise in Spinal Rats
Hyper-reflexia, measured as a decrease of low frequency-dependent depression of the H-reflex, is known to occur in both humans and animals after spinal cord injury (SCI). Previous studies have shown that passive exercise for 3 months could be used to restore low frequency-dependent depression of the H-reflex after SCI. To determine the effects of various periods of time on the ability of passive exercise to restore low frequency-dependent depression of the H-reflex. Spinal Cord Injury Mobilization Program of the Center for Translational Neuroscience, the research arm of the Jackson T Stephens Spine and Neuroscience Institute, Little Rock, AR, USA. Adult rats underwent complete spinal cord transection at the T10 level. The hindlimbs were passively exercised in different groups of rats for 1 h/day, 5 days/week for 15, 30, 45, 60, or 90 days, and low frequency-dependent depression of the H-reflex was tested. Statistically significant low frequency-dependent depression of the H-reflex was evident by 30 days of exercise, although numerical reductions were seen even at 15 days. There was a linear decrease in low frequency-dependent depression of the H-reflex with duration of passive exercise. Passive exercise can restore frequency-dependent depression of spinal reflexes in a time-dependent manner if used following complete spinal transection
Defects in Chiral Columnar Phases: Tilt Grain Boundaries and Iterated Moire Maps
Biomolecules are often very long with a definite chirality. DNA, xanthan and
poly-gamma-benzyl-glutamate (PBLG) can all form columnar crystalline phases.
The chirality, however, competes with the tendency for crystalline order. For
chiral polymers, there are two sorts of chirality: the first describes the
usual cholesteric-like twist of the local director around a pitch axis, while
the second favors the rotation of the local bond-orientational order and leads
to a braiding of the polymers along an average direction. In the former case
chirality can be manifested in a tilt grain boundary phase (TGB) analogous to
the Renn-Lubensky phase of smectic-A liquid crystals. In the latter case we are
led to a new "moire" state with twisted bond order. In the moire state polymers
are simultaneously entangled, crystalline, and aligned, on average, in a common
direction. In the moire state polymers are simultaneously entangled,
crystalline, and aligned, on average, in a common direction. In this case the
polymer trajectories in the plane perpendicular to their average direction are
described by iterated moire maps of remarkable complexity, reminiscent of
dynamical systems.Comment: plain TeX, (33 pages), 17 figures, some uufiled and included, the
remaining available at ftp://ftp.sns.ias.edu/pub/kamien/ or by request to
[email protected]
A randomized phase I study of the safety and immunogenicity of three ascending dose levels of a 3-antigen Staphylococcus aureus vaccine (SA3Ag) in healthy adults
Background: Staphylococcus aureus is a common cause of healthcare-acquired morbidity and mortalityand increased healthcare resource utilization. A prophylactic vaccine is being developed that may reducethis disease burden.Methods: Volunteers in good general health aged 50–85 (n = 312) and 18–24 (n = 96) years were random-ized to receive a single intramuscular dose of one of three dose levels of a non-adjuvanted, 3-antigen S.aureus vaccine (SA3Ag) or placebo. SA3Ag antigens included capsular polysaccharides 5 and 8 (CP5 andCP8), each conjugated to cross-reactive material 197 (CRM197), and recombinant clumping factor A (ClfA).Safety, tolerability, and immunogenicity were evaluated.Results: At day 29 post-vaccination, robust immune responses were observed in both age cohorts at allthree SA3Ag dose levels. In the primary analysis population, the 50- to 85-year age stratum, geometricmean-fold-rises in competitive Luminex® immunoassay antibody titers from baseline ranged from 29.2to 83.7 (CP5), 14.1 to 31.0 (CP8), and 37.1 to 42.9 (ClfA), all (P < 0.001) exceeding the pre-defined two-fold rise criteria. Similar rises in opsonophagocytic activity assay titers demonstrated functionality ofthe immune response. Most injection-site reactions were mild in severity and there were no substantial differences (SA3Ag vs. placebo) with regard to systemic or adverse events.Conclusions: In this study of healthy adults aged 50–85 and 18–24 years, SA3Ag elicited a rapid and robustimmune response and was well tolerated, with no notable safety concerns.Michael Nissen, Helen Marshall, Peter Richmond, Sepehr Shakib, Qin Jiang, David Cooper, Denise Rill, James Baber, Joseph Eiden, William Gruber, Kathrin U. Jansen, Emilio A. Emini, Annaliesa S. Anderson, Edward T. Zito, Douglas Girgent
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